Browse recent medication, recall, and health-related stories.
Page 41 of 51
The Medical Center at Bowling Green is the first hospital in the region to offer new treatment for metastatic prostate cancer.
—Increased confidence on cell therapy system approach for Type 1 diabetes ITHACA, N.Y., Sept. 23, 2026 /PRNewswire/ -- Through a recent INTERACT meeting with the Food and Drug Administration Center for Biologics Evaluation and Research (CBER), Persista Bio, Inc. received positive feedback...
XtalPi AI platform accelerates HIV-1 drug candidate selection within seven months Vietnam Investment Review - VIR
(NaturalNews) Gias Foods of New York is recalling two lots of bettergoods Authentic Italian Lemon Alfredo Fettuccine over concerns that the frozen pasta may be cont...
RGCIRC hosted NURSICON 2026, highlighting oncology nurses’ expanding roles in patient safety, supportive care, rehabilitation and survivorship, while stressing caregiver wellbeing, professional development and multidisciplinary cancer care.
Agreement: I Agree Body: Dear Editor, Daneshvar and colleagues provide important evidence that chronic traumatic encephalopathy (CTE) constitutes a substantial neuropathological burden among former National Football League players who died during the study period.[1] The remaining uncertainty, however, extends beyond selection into brain donation. From the perspective of researchers studying neural injury, synaptic plasticity, and cognitive dysfunction, the central unresolved question is how a pathological stage measured at death should be connected to functional decline that began years earlier. In this study, CTE stage was determined only at autopsy, whereas dementia developed during life. Dementia began at a mean age of 63.4 years, while donors with stage IV CTE died at a mean age of 76.4 years. Thus, the analysis cannot establish whether stage IV pathology was already present when dementia began, whether pathology progressed from a lower stage during the interval between dementia onset and death, or whether both reflected a longer period of ageing and neurodegeneration. This distinction matters because CTE stage is itself strongly age dependent and is associated with survival after football exposure.[2] Adjustment for age at death cannot reconstruct this unobserved temporal sequence. A related issue is the biological gap between pathological burden and functional expression. Stage IV CTE may identify not only extensive CTE-related tau deposition but a broader state of neural network injury. Among donors with stage IV CTE, 77.9% had TDP-43 pathology, while vascular abnormalities, white matter rarefaction, Alzheimer-type changes, and Lewy body disease were also common.[1] Previous analyses of brain donors exposed to repetitive head impacts have shown that these pathologies are correlated and jointly contribute to dementia.[3] Cognitive impairment may therefore reflect the combined effects of tau distribution, white matter disconnection, synaptic dysfunction, vascular injury, other proteinopathies, and diminishing neural reserve, rather than CTE stage alone. Evidence that advanced CTE remains associated with dementia after excluding major comorbid neurodegenerative diagnoses strengthens its clinical relevance.[4] Nevertheless, exclusion of comorbidities does not establish that advanced CTE preceded dementia, and it creates a selected subgroup that differs from the frequent mixed-pathology presentation of older donors. Inverse probability weighting for donation likewise cannot resolve the temporal ordering of pathological progression and cognitive decline. The reported risk ratio should therefore be interpreted as an association between dementia and a high-stage terminal pathological state, rather than as an estimate of the independent effect of CTE on dementia. Analyses of stage-specific age-standardised absolute risks, non-linear age effects, dementia-to-death intervals, regional tau burden, and interactions with TDP-43, vascular, white matter, and Alzheimer-type pathologies would help distinguish CTE-specific associations from a broader multipathological syndrome. Prospective cognitive and neurophysiological assessment, longitudinal imaging and fluid biomarkers, and eventual neuropathological confirmation are needed to determine when pathological progression becomes functionally consequential. Bridging this pathology-to-function gap is essential before advanced CTE at death can be interpreted as the process that caused dementia during life. References 1. Daneshvar DH, Nowinski CJ, Abdolmohammadi B, et al. Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21. BMJ. 2026;394:e100418. doi:10.1136/bmj-2026-100418. 2. Alosco ML, Cherry JD, Huber BR, et al. Characterizing tau deposition in chronic traumatic encephalopathy: utility of the McKee CTE staging scheme. Acta Neuropathol. 2020;140:495-512. doi:10.1007/s00401-020-02197-9. 3. Saltiel N, Tripodis Y, Menzin T, et al. Relative contributions of mixed pathologies to cognitive and functional symptoms in brain donors exposed to repetitive head impacts. Ann Neurol. 2024;95:314-324. doi:10.1002/ana.26823. 4. Layden RM, Groh JR, Miner AE, et al. CTE neuropathology alone is associated with dementia and cognitive symptoms. Alzheimer's Dement. 2026;22:e71032. doi:10.1002/alz.71032. No competing Interests: Yes The following competing Interests: Electronic Publication Date: Wednesday, September 23, 2026 - 04:20 AI use: No, I have not used AI Highwire Comment Subject: Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21 Workflow State: Released Full Title: CTE stage is not yet a timeline: bridging terminal pathology and functional decline Highwire Comment Response to: Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21 Check this box if you would like your letter to appear anonymously:: Last Name: Kong First name and middle initial: Yue Email: kongy@dmu.edu.cn Address: No. 9, West Section, Lvshun South Road, Dalian, Liaoning 116044, P.R. China Occupation: Experimentalist Other Authors: Yifan Zhao; Shao Li Affiliation: Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University. BMJ: Additional Article Info: Rapid response
Type 2 diabetes is increasingly affecting young adults in Germany, with new evidence showing poverty, low education and first-generation migration background as factors associated with the disease. A study from the Leibniz Institute for Prevention Research and Epidemiology—BIPS, using data from the German National Cohort (NAKO), finds that these social disparities persist even after accounting for family history and individual lifestyle, prompting calls for a shift from purely behavioral advice to structural environment-focused prevention.
Clearfork Academy (888-430-5149) has expanded its drug and alcohol rehab programs for teens, now offering more options for its PHPs and IOPs.
GF Blends is recalling Truly AIP All Purpose Flour and Bread Mix and EAT G.A.N.G.S.T.E.R. Flat Bread Pizza Mix listed below due to potential undeclared wheat gluten. People who have celiac disease or a severe gluten intolerance run the risk of adverse
—Increased confidence on cell therapy system approach for Type 1 diabetes ITHACA, N.Y., Sept. 23, 2026 /PRNewswire/ -- Through a recent INTERACT meeting with the Food and Drug Administration Center for Biologics Evaluation and Research (CBER), Persista Bio, Inc. received positive feedback...
RGCIRC hosted NURSICON 2026, highlighting oncology nurses’ expanding roles in patient safety, supportive care, rehabilitation and survivorship, while stressing caregiver wellbeing, professional development and multidisciplinary cancer care.
Agreement: I Agree Body: Dear Editor, Daneshvar and colleagues provide important evidence that chronic traumatic encephalopathy (CTE) constitutes a substantial neuropathological burden among former National Football League players who died during the study period.[1] The remaining uncertainty, however, extends beyond selection into brain donation. From the perspective of researchers studying neural injury, synaptic plasticity, and cognitive dysfunction, the central unresolved question is how a pathological stage measured at death should be connected to functional decline that began years earlier. In this study, CTE stage was determined only at autopsy, whereas dementia developed during life. Dementia began at a mean age of 63.4 years, while donors with stage IV CTE died at a mean age of 76.4 years. Thus, the analysis cannot establish whether stage IV pathology was already present when dementia began, whether pathology progressed from a lower stage during the interval between dementia onset and death, or whether both reflected a longer period of ageing and neurodegeneration. This distinction matters because CTE stage is itself strongly age dependent and is associated with survival after football exposure.[2] Adjustment for age at death cannot reconstruct this unobserved temporal sequence. A related issue is the biological gap between pathological burden and functional expression. Stage IV CTE may identify not only extensive CTE-related tau deposition but a broader state of neural network injury. Among donors with stage IV CTE, 77.9% had TDP-43 pathology, while vascular abnormalities, white matter rarefaction, Alzheimer-type changes, and Lewy body disease were also common.[1] Previous analyses of brain donors exposed to repetitive head impacts have shown that these pathologies are correlated and jointly contribute to dementia.[3] Cognitive impairment may therefore reflect the combined effects of tau distribution, white matter disconnection, synaptic dysfunction, vascular injury, other proteinopathies, and diminishing neural reserve, rather than CTE stage alone. Evidence that advanced CTE remains associated with dementia after excluding major comorbid neurodegenerative diagnoses strengthens its clinical relevance.[4] Nevertheless, exclusion of comorbidities does not establish that advanced CTE preceded dementia, and it creates a selected subgroup that differs from the frequent mixed-pathology presentation of older donors. Inverse probability weighting for donation likewise cannot resolve the temporal ordering of pathological progression and cognitive decline. The reported risk ratio should therefore be interpreted as an association between dementia and a high-stage terminal pathological state, rather than as an estimate of the independent effect of CTE on dementia. Analyses of stage-specific age-standardised absolute risks, non-linear age effects, dementia-to-death intervals, regional tau burden, and interactions with TDP-43, vascular, white matter, and Alzheimer-type pathologies would help distinguish CTE-specific associations from a broader multipathological syndrome. Prospective cognitive and neurophysiological assessment, longitudinal imaging and fluid biomarkers, and eventual neuropathological confirmation are needed to determine when pathological progression becomes functionally consequential. Bridging this pathology-to-function gap is essential before advanced CTE at death can be interpreted as the process that caused dementia during life. References 1. Daneshvar DH, Nowinski CJ, Abdolmohammadi B, et al. Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21. BMJ. 2026;394:e100418. doi:10.1136/bmj-2026-100418. 2. Alosco ML, Cherry JD, Huber BR, et al. Characterizing tau deposition in chronic traumatic encephalopathy: utility of the McKee CTE staging scheme. Acta Neuropathol. 2020;140:495-512. doi:10.1007/s00401-020-02197-9. 3. Saltiel N, Tripodis Y, Menzin T, et al. Relative contributions of mixed pathologies to cognitive and functional symptoms in brain donors exposed to repetitive head impacts. Ann Neurol. 2024;95:314-324. doi:10.1002/ana.26823. 4. Layden RM, Groh JR, Miner AE, et al. CTE neuropathology alone is associated with dementia and cognitive symptoms. Alzheimer's Dement. 2026;22:e71032. doi:10.1002/alz.71032. No competing Interests: Yes The following competing Interests: Electronic Publication Date: Wednesday, September 23, 2026 - 04:20 AI use: No, I have not used AI Highwire Comment Subject: Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21 Workflow State: Released Full Title: CTE stage is not yet a timeline: bridging terminal pathology and functional decline Highwire Comment Response to: Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21 Check this box if you would like your letter to appear anonymously:: Last Name: Kong First name and middle initial: Yue Email: kongy@dmu.edu.cn Address: No. 9, West Section, Lvshun South Road, Dalian, Liaoning 116044, P.R. China Occupation: Experimentalist Other Authors: Yifan Zhao; Shao Li Affiliation: Liaoning Provincial Key Laboratory of Cerebral Diseases, Institute for Brain Disorders, Dalian Medical University. BMJ: Additional Article Info: Rapid response
Type 2 diabetes is increasingly affecting young adults in Germany, with new evidence showing poverty, low education and first-generation migration background as factors associated with the disease. A study from the Leibniz Institute for Prevention Research and Epidemiology—BIPS, using data from the German National Cohort (NAKO), finds that these social disparities persist even after accounting for family history and individual lifestyle, prompting calls for a shift from purely behavioral advice to structural environment-focused prevention.
GF Blends is recalling Truly AIP All Purpose Flour and Bread Mix and EAT G.A.N.G.S.T.E.R. Flat Bread Pizza Mix listed below due to potential undeclared wheat gluten. People who have celiac disease or a severe gluten intolerance run the risk of adverse